Protein Details: Cation channel sperm-associated auxiliary subunit zeta

Function

Auxiliary component of the CatSper complex; a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for a distribution of the CatSper complex in linear quadrilateral nanodomains along the flagellum; maximizing fertilization inside the mammalian female reproductive tract. Together with EFCAB9; associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel.

Sequence

PDB Structures

Ligand Binding